Acs Synthetic Biology

Driving In Vivo Multienzyme Cascades Forward: Regulatory Strategies for Enhanced Biocatalysi

Author: Yang, Qing; Zhu, Fang-ying; Zhang, Xiao-jian; Cai, Xue; Zhou, Jun-ping; Liu, Zhi-qiang; Zheng, Yu-guo

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1282-1299. DOI: 10.1021/acssynbio.5c00951

Directed Evolution of Glutamate Dehydrogenase for Oxaloacetate Amination and Biosynthesis of Aspartate-Derived Chemical

Author: Cao, Chenkai; Nie, Mengzhen; Bi, Yanqi; Wang, Yuchen; Zhang, Kechun

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1568-1576. DOI: 10.1021/acssynbio.5c00965

Multifunctional Roles and Microbial Production Bottlenecks of Ergothionein

Author: Ma, Zhi; Qin, Chen; Deng, Yanfeng; Guo, Xinying; Zhu, Linjiang; Zhu, Dianhao; Chen, Xiaolong

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1249-1263. DOI: 10.1021/acssynbio.5c00735

Uncovering the Functional Role of UGT73F/P Subfamilies toward Triterpenoids Glycosylation in Legume Medicinal Plant

Author: Zhang, Liang; Liu, Xinhe; Li, Yongxing; Feng, Xudong; Li, Chun

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1327-1339. DOI: 10.1021/acssynbio.5c00740

Functional and Mechanistic Characterization of VacPT, a Novel cis-Prenyltransferase from Vibrio alginolyticu

Author: Ma, Yuzhen; Du, Shuangshuang; Wang, Pengyu; Liu, Jiajia; Zhang, Jiaqi; Qi, Yanwen; Zhao, Xiaoli; Meng, Xiangfeng; Shi, Chao; Ma, Cuiping

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1375-1388. DOI: 10.1021/acssynbio.5c00784

Targeting Barrier Reinforcement and MAPK Inhibition: Recombinant Mucin-Type Collagen Tandems Ameliorate Inflammation in TNF-α/IFN-γ-Induced Atopic Dermatitis-like HaCaT Keratinocyte

Author: Zhao, Zilong; Yuwen, Weigang; Fan, Daidi

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1480-1492. DOI: 10.1021/acssynbio.5c00876

An Anaerobic Fluorescent Reporter System and CRISPR-Cas12a Enable High-Throughput Metabolic Engineering of Clostridium butyricu

Author: Li, Diying; Feng, Jing; Wang, Xiying; Zhao, Erlong; Liang, Yunxiang; Li, Keke; Li, Yingjun

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1669-1680. DOI: 10.1021/acssynbio.6c00158

A Constrained Degron Tag Engineered to Enhance Auxin-Inducible Protein Degradatio

Author: Han, Zhenlin; Alkhadrawi, Adham; Tofani, Solange; Zhang, Wei; Chi, L. America; Maruwan, Jessica; Patel, Jagdish Suresh; Su, Wei Wen

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1577-1587. DOI: 10.1021/acssynbio.5c00970

Engineering FeoB-Mediated Iron Uptake Enhances Butyrate Fermentation in Clostridium tyrobutyricu

Author: Zeng, Yu; Dong, Yuanda; Wang, Yuan; Wang, Mingyue; Wang, Weiguang; Zhang, Xuping; Suo, Yukai

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1658-1668. DOI: 10.1021/acssynbio.6c00109

Balancing Consecutive Two-Step Oxidations Catalyzed by a Single Cytochrome P450 Enables Efficient Biosynthesis of Plant Natural Product

Author: Chen, Yilin; Deng, Zhiwei; Zhang, Yan; Yuan, Zhenbo; Liu, Changmei; Luo, Zhengshan; Rao, Yijian

Journal: ACS SYNTHETIC BIOLOGY. 2026; Vol. 15, Issue 4, pp. 1617-1627. DOI: 10.1021/acssynbio.6c00016

Optimizing Oleaginous Yeast Cell Factories for Flavonoids and Hydroxylated Flavonoids Biosynthesis

引用次数：27

Combining 26s rDNA and the Cre-IoxP System for Iterative Gene Integration and Efficient Marker Curation in Yarrowia lipolytica

引用次数：21

A Post-translational Metabolic Switch Enables Complete Decoupling of Bacterial Growth from Biopolymer Production in Engineered Escherichia coli

引用次数：18

One-Pot Assembly of Complex Giant Unilamellar Vesicle-Based Synthetic Cells

引用次数：17

Quantification of Interlaboratory Cell-Free Protein Synthesis Variability

引用次数：16

Promoter Engineering for Enhanced P(3HB-co-4HB) Production by Halomonas bluephagenesis

引用次数：15

Highly Effective and Low-Cost MicroRNA Detection with CRISPR-Cas9

引用次数：14

Systematic Analysis of Bottlenecks in a Multibranched and Multilevel Regulated Pathway: The Molecular Fundamentals of L-Methionine Biosynthesis in Escherichia coli

引用次数：14

Highly Active C-8-AcyI-ACP Thioesterase Variant Isolated by a Synthetic Selection Strategy

引用次数：13

SynBioHub: A Standards-Enabled Design Repository for Synthetic Biology

引用次数：13